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Funding agency
European Commission, Horizon 2020
IUS Project Coordinator
Assoc. Prof. Dr. Kanita Karadjuzovic-Hadziabdic
Start date
End date
Project Summary

The COVIRNA project aims to generate a diagnostic test based on cardiovascular RNA biomarkers highly predictive of the clinical outcomes of COVID-19 patients and to enable its rapid market uptake to improve individualized surveillance, care, and follow-up of these patients in the context of the current pandemic.


Objective: At the technological and research levels

  • To build a biobank of 2,000 blood samples from existing cohorts of COVID-19 patients throughout Europe to perform a retrospective multicentre international study;
  • To achieve biomarker qualification and select a subset of highly specific lncRNAs predictive of COVID-19 clinical outcome using bioinformatics, artificial intelligence (AI), and biostatistics;
  • To build a disease evolution prediction model based on selected lncRNAs and clinical data;
  • To design a reliable, cost-efficient, and easy-to-use in vitro diagnostic (IVD) test to predict COVID19 clinical outcomes.


Objective: At the socio-economic and regulatory levels

  • To achieve CE marking of the innovative COVIRNA prognostic solution;
  • To establish a strategic science-policy-business-society consultation to optimize the design of the diagnosis solution complying with end-user's needs, cost-efficiency analysis requirements, current EU regulation, and highest quality standards to enable and accelerate their uptake into clinical practice;
  • To raise stakeholders' awareness of the advantages brought by the newly designed diagnostic solution as a valuable decision-support tool for healthcare professionals to deliver the best health outcome for the most vulnerable COVID-19 patients through a tailored dissemination programme;
  • Engage communities of stakeholders in sharing practical knowledge on the use of novel medical technology.
  • Luxembourg Institute of Health (LIH)
  • Internacionalni Univerzitet U Sarajevu (IUS)
  • Firalis SA (Firalis)
  • Université du Luxembourg (UNILU)
  • Imperial College of Science and Technology Medicine (Imperial)
  • Universiteit Maastricht (UM)
  • European Health Management Association (EHMA)
  • Heinrich-Heine-Universitaet Duesseldorf (UDUS)
  • The University of Edinburgh (UEDIN)
  • Policlinico San Donato SPA (PSD)
  • Pharmahungary 2000 Kiserletes Es Klinikai Kutatasfejlesztesi Korlatolt                 Felelossegu Tarsasag (PharmaHU)
  • Universitaet Leipzig (ULEI)
  • Jožef Stefan Institute (JSI)
  • Fundacio Privada Institut de Recerca de l`Hospital de la Santa Creu i Sant Pau (IR-HSCSP)
  • Universidade de Coimbra (UCO)

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